From a near-infinite set of possibilities, we can predict how viruses evolve and design vaccines that protect against both today’s and tomorrow’s threats.
Reimagining vaccinology.
Octavia
[ ok-tey-vee-uh ] noun
Meet Octavia™
Octavia is our biology-enabled AI/ML platform.
Octavia profiles viruses based on their current and future ability to evade the immune system and delivers a view of a virus’s evolutionary potential. By creating maps of viral fitness, we predict and engineer optimized vaccine antigens with the goal of programming the ideal immune response.
Unlike fully computational approaches, our platform is designed from the bottom-up to seamlessly integrate proprietary biological data with our AI/ML models. Octavia has demonstrated the ability to accurately assess a viral landscape and define key features that are then engineered into superior vaccines. Our model framework allows us to predict vaccine performance against both existing and future viral threats.
Here's how it works:
Apriori isolates a key protein fragment from the target virus
We then design and screen large libraries with human sera to generate proprietary datasets that detail viral fitness
These datasets then feed computational models to predict which parts of the viral protein should be included in a vaccine to elicit the most effective immune response
With these insights, we engineer proprietary antigens that are optimized to drive broader, more stable, and more potent immune responses
With our unique experimental workflow, we then predict the performance of the engineered antigens with several delivery platforms, resulting in a tailored antigen that outperforms current standard of care vaccines, promising improved global health outcomes
